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ENHPATHY highlighted in the Winter issue of EU Research

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Studying enhancer function to understand human disease

Enhancers play an important role in determining how genes are expressed in different cells in the body. The goal of the ENHPATHY consortium is to identify these enhancers and how they regulate gene expression. Knowledge about enhancer function may eventually lead to new treatments against diseases associated with enhancer dysfunction. 

 
Read the Winter issue
More about EU Research 
Please cite if you share this article : Spicuglia, S., Ferrer, J. (2023). ‘Studying enhancer function to understand human disease’, EU Research, Winter 2023 vol. (37), pp. 10 – 12.

 

12 January 2024/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2024/01/New-Dissemination-l.jpg 1000 1000 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2024-01-12 09:56:592024-01-12 10:37:52ENHPATHY highlighted in the Winter issue of EU Research

Exploration from genome research to cyber biology and modern life

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Check my Enhancer in Art project presented in collaboration with artist Zijun Feng.

9 October 2023/by Jing Wan
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Jing-Zijun.jpg 800 800 Jing Wan https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Jing Wan2023-10-09 11:18:222023-10-18 10:49:41Exploration from genome research to cyber biology and modern life

HPE101

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Check my Enhancer in Art project presented in collaboration with artist Minh Hoang.

9 October 2023/by Sarah Malika Robert
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Sarah-Minh-Hoang.jpg 800 800 Sarah Malika Robert https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Sarah Malika Robert2023-10-09 11:16:382023-10-18 10:53:12HPE101

Sentinels

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Check my Enhancer in Art project presented in collaboration with artist Ondrej Mistrik.

9 October 2023/by Irina Ribeiro-Bas
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Irina-Ondrej.jpg 800 800 Irina Ribeiro-Bas https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Irina Ribeiro-Bas2023-10-09 11:14:252023-10-18 11:04:23Sentinels

To discover…

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Check my Enhancer in Art project presented in collaboration with artists Kochamon Manprasatkul & Kalyarat “Farng” Kuropakornpong.

9 October 2023/by Natsuda Navamajiti
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Natsuda.jpg 800 800 Natsuda Navamajiti https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Natsuda Navamajiti2023-10-09 11:12:582023-10-18 11:38:08To discover…

Synergy

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Check my Enhancer in Art project presented in collaboration with artist Anna Stankevich.

9 October 2023/by Olga Pushkareva
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Olga.jpg 800 800 Olga Pushkareva https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Olga Pushkareva2023-10-09 11:10:532023-10-18 13:40:36Synergy

Decoder lens

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Check my Enhancer in Art project presented in collaboration with artist Dimple Devadas.

9 October 2023/by Veronica Erconi
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Veronica-2.jpg 800 800 Veronica Erconi https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Veronica Erconi2023-10-09 11:09:312023-10-18 14:07:05Decoder lens

The scientist’s journey

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Check my Enhancer in Art project presented in collaboration with artist Annelie Martens.

9 October 2023/by Anna Karina Felder
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Anna-F.jpg 800 800 Anna Karina Felder https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Anna Karina Felder2023-10-09 11:07:362023-10-18 18:50:30The scientist’s journey

Pillars of identity

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Check my Enhancer in Art project presented in collaboration with artist Laura K. Holm.

9 October 2023/by Anna Cetnarowska
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Anna-C.jpg 800 800 Anna Cetnarowska https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Anna Cetnarowska2023-10-09 11:05:582023-10-18 14:00:15Pillars of identity

Imbalance, scaling impact

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Check my Enhancer in Art project presented in collaboration with artist Dimple Devadas.

9 October 2023/by Gaurav Mandana
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Veronica.jpg 800 800 Gaurav Mandana https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Gaurav Mandana2023-10-09 11:04:292023-10-18 14:04:31Imbalance, scaling impact

Bulbul in the loop

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Check my Enhancer in Art project presented in collaboration with artist Tejeswini Padma.

9 October 2023/by Abhishek Agarwal
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Abhishek.jpg 800 800 Abhishek Agarwal https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Abhishek Agarwal2023-10-09 11:01:202023-10-18 14:23:02Bulbul in the loop

Distance

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Check my Enhancer in Art project presented in collaboration with artist Ekaterina Onufrienko.

9 October 2023/by Artemy Zhigulev
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Artemy.jpg 800 800 Artemy Zhigulev https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Artemy Zhigulev2023-10-09 10:58:322023-10-18 14:10:20Distance

Catophony

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Check my Enhancer in Art project presented in collaboration with artist Alyona.

9 October 2023/by Maksim Kholmatov
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Maksim.jpg 800 800 Maksim Kholmatov https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Maksim Kholmatov2023-10-09 10:56:472023-10-18 14:18:20Catophony

Intricacies of the human genome

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Check my Enhancer in Art project presented in collaboration with artist Iwan Vaandrager.

9 October 2023/by Vartika Bisht
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Vartika-Iwan.jpg 800 800 Vartika Bisht https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Vartika Bisht2023-10-09 10:54:262023-10-18 11:22:15Intricacies of the human genome

From Science to Art…and beyond

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Check my Enhancer in Art project presented in collaboration with artist Alessandro Ventura.

9 October 2023/by Francesco Leonetti
https://www.enhpathy.eu/wp-content/uploads/2023/10/EIA-Project-Francesco.jpg 800 800 Francesco Leonetti https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Francesco Leonetti2023-10-09 10:37:222023-10-18 14:25:27From Science to Art…and beyond

Pitch my Enhancer in art project in 90 seconds

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On June 15th, our 15 students will face the challenge of presenting their Enhancer in art project to a lay audience. One condition: not to exceed 90 seconds!

 
Register to watch the presentations live on Youtube.
 
About Enhancer in art: Enhancer in art is a science/art program that offers an artist the unique opportunity to become an actor in a European scientific program by creating an original artwork in collaboration with one of our PhD students.
Learn more: https://www.enhpathy.eu/communication…
 
We would like to thank all the artists who have agreed to take part in this programme:

Tejeswini Padma Iwan Vaandrager ( https://lnkd.in/evWv3aDe ) Dr Dimple Devadas FRSA Annelie Mollbrink PhD Alyona Buglakova ( https://lnkd.in/ezQEetVy ) Laura K. Holm Alessandro Ventura Kochamon Manprasatkul Anastasia Stankevich ( https://lnkd.in/e86jf7mJ ) Ondrej Mistrik ( https://lnkd.in/egT63x6D ) Minh Hoang ( https://lnkd.in/evyMMdWk ) Zijun Feng ( https://lnkd.in/evv5xdhS ) Ekaterina Onufrienko ( https://lnkd.in/ePa76buV )
 
About Enhpathy:
Enhpathy is a multidisciplinary scientific consortium created in the framework of the Marie Sklodowska-Curie Actions (MSCA-Doctoral Networks), bringing together 15 academic and 9 non-academic European organizations in the continuum of basic, translational and clinical research on enhancers and related diseases.
Learn more: https://www.enhpathy.eu/
 
To view our PhD students’ profiles and to contact them: https://www.enhpathy.eu/team/
 
Follow Enhpathy on Twitter: https://twitter.com/enhpathy_H2020

 

30 May 2023/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2023/05/Pitch-EIA.jpg 1000 1000 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2023-05-30 12:06:092023-06-14 09:03:40Pitch my Enhancer in art project in 90 seconds

Using AI to make a bridge between Science and Art

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The fascinating objective to connect Science and Art under the project “Enhancer in Art” has made registered some good progress on my side.
I had the pleasure to meet Alessandro, the artist who will accompany me during this ambitious project.

First: let me introduce you to Alessandro!
Since he was a child, his passions are the photography and the informatic. He used to spend time observing the pictures he found in photography books. His favorites were especially those concerning natural landscapes. He used to stare at them and imagine himself carrying inside!

Thus, over time he cultivated his passions, getting his first degree in “Photography” at Institut d’Estudis Fotogràfics de Catalunya (IEFC), followed by a Master’s degree in “Film editor” at Escola Superior de Cinema Audiovisuals de Catalunya (ESCAC) in Barcelona.

Nowadays the digital art is having an explosion of notoriety. Our project idea comes from trying to mix photography, paintings, research, images of the results of experiments, our passions, and our jobs. More precisely, the artificial intelligence (AI) used today in all fields from photography to software programming in scientific research.

This project, I hope, will be a great opportunity for us young researchers to “communicate” our work, making it easier and closer to the general public in an innovative way.

I look forward to continue working with Alessandro, full of expectations for the final result.

So, for upcoming updates, STAY TUNED!

Ref:
https://www.instagram.com/aventuraphotos/

https://www.linkedin.com/in/aventuraphotos/

 

“Creativity in photography” one of Alessandro’s recent projects

 

 

Alessandro

24 May 2023/by Francesco Leonetti
https://www.enhpathy.eu/wp-content/uploads/2023/05/Screenshot-2023-05-24-at-12.17.22-1.png 932 1347 Francesco Leonetti https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Francesco Leonetti2023-05-24 12:12:562023-05-24 12:25:13Using AI to make a bridge between Science and Art
The shared emotion behind art and science

The shared emotion behind science and art

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 “Art and science aim to unveil the universal perception of the subjects they examine.”

Both art and science seek to impact humanity by  donating a meaningful story. Their efforts are consistently focused in reflecting and understanding the nature of our world. They both move fast, while intending to remain time-less. Art, as an universal language, helps science to be more accessible to a broader public. Science in return, has been a source of inspiration for many artists throughout history. Both have faced, and still do, endless difficulties in their mission to shed a light of truth. They require sacrifice, resilience, and patience.  Both are exciting, unpredictable and consequential. Their resemblance increases the more one thinks about them.

What I just wrote, is nothing new. We have heard of the bright sides of art and science, and we know first hand, how beautiful they can be. To give it a twist, I will dive into some of the common struggles that artists and scientists share during their discovery journey. A small reminder before the next lines: this is of course, an opinion article. Feel free to skip the chapters you don’t see your self reflected into.

The shared emotion behind science and art
Chapter one: self doubt

To create, does not come with ease. To be able to stand out in this journey, is an even more challenging task. The new-born artist, as the new-born scientist,  enter a world where our own self-worth is often at stake. We mostly do so with innocence and a hand full of  ideas, confidence and dreams. Inevitably during the first years of our career, and for as long we  remain being artists and scientists, our  ideas and discoveries will undergo a merciless process of trial and error. Our work will become an absolute reflection of how capable, bright, and resourceful creators we are.

I might be adding some theatricals to embellish this thought. But, wouldn’t you agree? When we are working on an experiment over and over and we do not succeed..  one might start questioning their own capacity to perform it. One might start to fear of what their supervisor or colleagues might think.  Am I good enough?  I presume, you can think of some intrusive thoughts that hunt us in this situations.  I would imagine, that artists go through the same experience when they are trying to figure out, for example, which is their own style. They might doubt themselves. They might get hit by the popular “impostor syndrome”. And sometimes, so do we, scientists.

Chapter two:  uncertainty

Artists and scientist do not only share a goal, but we also face a sense of vulnerability and uncertainty that often threatens our work. The principle behind, is that regardless our efforts, there is no guarantee, to achieve what we intend to.

An artist can have created with an imaginative hand and can have persisted until shaping the exact shade of emotion they wanted to capture. Nevertheless, it is likely, that asides from the closest circle of people surrounding them, no one will ever appreciate their work. Artists need to live with the possibility of their piece never being shown at a gallery or complimented by an expert. In in other words, that their work does not become transcendental.

In the exact shape, only a small percentage of scientists will make it to a big name and will be able to deliver an essential missing piece of information or develop a novel technique. Not every scientist will be able to publish in the highest impact factor journal.  For some of us, a small contribution to a bigger picture will be the work of our lives.

We do know, that uncertainty can be one of the reasons why remaining an artist or a scientist during the years, is considered by many, something to admire.

Chapter three: time

 For artists and scientists: Days are weekends that are months. Evenings are hours that are already mornings.

A lot of time. Not enough time

I think there are no words needed for this chapter.

Chapter four: acceptance

Both artist and scientists have to face this chapters at some point of their career. They have to face many other more, that I have intentionally omitted.

To do so, I think we need to feel fulfilled by our life choice. I have heard that often artists see their creation as a part of themselves. I would say, we scientists relate to our work in a very similar way.  The artist and the art, and the scientist and the science. It is a one of a kind connection that makes us accept all of this facts, with a blink of an eye.

Chapter five: success does not equal fame

And now, a small reflection that might help, when are stuck in one of this chapters.

That artists or scientists do not become a recognized figure, does not mean that they did not have brilliant ideas and a fantastic story to tell. Think of the times, when artists and scientists have brought concepts that the world was not ready for yet. For your inspiration:

 Ada Lovelace (nationalgeographic.com)

Greco (Doménikos Theotokópoulos). Museo Nacional Thyssen-Bornemisza (museothyssen.org)

 

There are difficulties in science that are beyond of our control. Same applies to artists. I am sure you can also think of a couple of examples.  It repeatedly happens that an artist and scientist might have the brightest idea but lack the resources to conduct it. Other times, they might have perfected their story, but not have the opportunity to make it available to the desired public. Or it might not be recognized in the way it deserves. The list goes on and on.

I am under the impression, that success, does not often correlate with the personal capacity of the artist or the scientist to shape a new story into this world. And I think, that keeping this in mind, might actually help us avoid falling into these chapters.

 

With this, the end of my article.

 

An unknown artist for my take on art and science

The shared emotion behind art and scienceO.M.

In my (humble) opinion,

Art and science, to be truly enjoyed, should be done without any higher expectation of fame or greatness. That is why, in my take on enhancers in art, I would like to stay truthful to my thoughts. I intend to give the opportunity that Enhpathy offers to a new artist. I hope that by doing this, I will be able to convince you, that artists and scientists go hand in hand in the journey of creation.

Read more

23 January 2023/by Irina Ribeiro-Bas
https://www.enhpathy.eu/wp-content/uploads/2021/04/emotionbehindartandscience.jpg 655 797 Irina Ribeiro-Bas https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Irina Ribeiro-Bas2023-01-23 21:49:042023-01-28 10:49:03The shared emotion behind science and art

Current challenges in understanding the role of enhancers in disease

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Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing evidence that enhancer dysfunction due to genetic, structural or epigenetic mechanisms contributes to a broad range of human diseases referred to as enhanceropathies. Such mechanisms often underlie the susceptibility to common diseases, but can also play a direct causal role in cancer or Mendelian diseases. Despite the recent gain of insights into enhancer biology and function, we still have a limited ability to predict how enhancer dysfunction impacts gene expression.

In this Perspective review published in the Nature Structural & Molecular Biology journal, the ENHPATHY researchers discuss the major challenges that need to be overcome when studying the role of enhancers in disease etiology and highlight opportunities and directions for future studies, aiming to disentangle the molecular basis of enhanceropathies.

Read more

 

8 December 2022/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2022/02/New-Publication.jpg 800 800 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2022-12-08 18:07:162022-12-08 18:07:16Current challenges in understanding the role of enhancers in disease

Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway

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New publication by Alberich-Jorda M and Sladana Kosanovic in EMBO reports.

Chronic inflammation represents a major threat to human health since long-term systemic inflammation is known to affect distinct tissues and organs. Recently, solid evidence demonstrated that chronic inflammation affects hematopoiesis; however, how chronic inflammation affects hematopoietic stem cells (HSCs) on the mechanistic level is poorly understood. Here, we employ a mouse model of chronic multifocal osteomyelitis (CMO) to assess the effects of a spontaneously developed inflammatory condition on HSCs. We demonstrate that hematopoietic and nonhematopoietic compartments in CMO BM contribute to HSC expansion and impair their function. Remarkably, our results suggest that the typical features of murine multifocal osteomyelitis and the HSC phenotype are mechanistically decoupled. We show that the CMO environment imprints a myeloid gene signature and imposes a pro-inflammatory profile on HSCs. We identify IL-6 and the Jak/Stat3 signaling pathway as critical mediators. However, while IL-6 and Stat3 blockage reduce HSC numbers in CMO mice, only inhibition of Stat3 activity significantly rescues their fitness. Our data emphasize the detrimental effects of chronic inflammation on stem cell function, opening new venues for treatment.

Link on the publication

 

 

16 November 2022/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2022/11/Publication-EMBO-reports-final.jpg 680 680 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2022-11-16 16:27:322022-11-16 16:36:02Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway

Scientific communication 101: A creative strategy to convey the wonder of your research

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Art and science are intuitively perceived as polar opposites: subjective versus objective, creative versus analytical. However, history provides us several examples of pivotal figures in science that have been able to wear the shoes of the scientist and the artist at once.

3 giants of art and science and their works

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

For instance, Santiago Ramón y Cajal (1852 – 1934), Spanish artist, photographer and neuroanatomist, dedicated fifty years to the study of the nervous system, producing a plethora of brilliant illustrations out of his observations. In one of his major writings, ‘The neuron doctrine’, he presented his theory considering neurons as individual cells sending and receiving information. This theory, recognized today as the basis of modern neuroscience, yielded in the assignment of Nobel Prize in Physiology or Medicine in 1906.

In addition, Maria Sibylla Merian (1647 – 1717), today acknowledged as one of the most important female scientists of the ‘Age of Reason’ and pioneer of modern entomology. Her observations helped dispel the popular belief that insects spontaneously emerged from mud. Moreover, her detailed descriptions and paintings of exotic insects, portrayed for the first time in their habitats, registered on-site during her travels to South America, inspired generations of artists and ecologists.

Finally, Leonardo da Vinci (1452 – 1519), among the greatest polymaths of the Renaissance, pursued art and science by following his boundless desire for knowledge and artistic expression. His artistic expression was not limited to drawings for inventions and experiences, but also lead him to the generation of masterpieces appreciated worldwide, such as Mona Lisa and Last Supper.

 

“To develop a complete mind: Study the science of art; Study the art of science. Learn how to see. Realize that everything connects to everything else.”
– Leonardo da Vinci

 

As a young researcher in the ENHPATHY consortium, I am invited to stand on the shoulders of these giants and explore the impact of art on the communication of the value of scientific efforts aiming to unravel the intricate world of gene regulation to the general public.

At the beginning of this adventure, I am looking forward to meet the chosen artist for an initial chat about my PhD project. If you are interested in this challenging experience, you can continue to follow the Enhancer in Art blog, where you will find interesting updates and the final result of this curious experiment.

 

Links for further reading:

  • https://www.nytimes.com/es/2017/02/21/espanol/cultura/santiago-ramon-y-cajal-el-hombre-que-dibujo-los-secretos-del-cerebro.html
  • https://www.nytimes.com/2017/01/23/science/maria-sibylla-merian-metamorphosis-insectorum-surinamensium.html
  • https://www.leonardodavinci.net

 

6 October 2022/by Veronica Erconi
https://www.enhpathy.eu/wp-content/uploads/2021/04/BlogPic_sepia_modif.png 2167 2268 Veronica Erconi https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Veronica Erconi2022-10-06 08:00:332022-10-06 08:37:06Scientific communication 101: A creative strategy to convey the wonder of your research

ENHPATHY ESRs visit the Novartis Institutes for BioMedical Research (NIBR)

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The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis. NIBR’s Scientists collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Visit NIBR

Learn more about the visit program

 

16 June 2022/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2022/06/NIBR_2.jpg 1536 1868 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2022-06-16 09:32:332022-06-20 09:23:41ENHPATHY ESRs visit the Novartis Institutes for BioMedical Research (NIBR)

Science & Art collaboration: the starting up of Enhancer in Art

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Encounter with Artist

Zijun is a master student who study in École supérieure d’art d’Aix-en-Provence Félix Ciccolini (ESAAIX), France. Before she switched into art, she was a product manager of IT company in China and Japan. The first time we met happened in the art exposition of Jeff Koons in Europe and Mediterranean Civilization Museum of Marseille. She introduced me an initial perspective on how to view art exhibitions that I had never set foot in. We talked each other about our working field, and realizing the potential collaboration because we both interested in cross-disciplinary collaboration.

Explorer in biological lab

So we started to explore the possibility of collaboration. We arranged a coffee meeting with Davide (ENHPATHY project manager) in the library of campus. We discussed the program plan of Enhancer in Art, what artist need from art part, what we can provide from science part and how to start up step by step. It’s very well and fully-discussed meeting between researcher, artist and manager. For knowing biology working better, I invited Zijun to visit our laboratory to show our daily scientific work. Zijun showed great interest in our daily biological experiment stuff and some materials we always ignored.

Researcher in artist working shop

In a campus opening weekend, I visited Zijun’s art college and working place in Aix-en-Provence, which locate in hometown of the famous Post-Impressionism artist, Paul Cézanne. It’s an impressive and novel conception explosion experience for me, as a person outside of art. The art working direction in ESAAIX involve all kinds of stuffs for material exploring and conception construction, like materials of plastic, wood, steel, silk, paper, ceramics; the conception of human body structure, gender, electronic games, machinery, 3D printing; the form of sound, visual, action, sense of touch. The painting only takes small part of modern art. All of these opened my mind to explore the crossing between biology research and art. And also let me know what kind of materials could be useful for artist and what kind of space and environment condition required by special art work.

Generally, I felt different kinds of working possibility and exciting for the following work. In the next, we are going to write a general proposal and exchange our idea for the concrete material, conception and format of Enhancer in Art.

Artist working shop and art works in creating
ESAAIX campus opening weekend

ESR, artist, KOM agency founder, scientist in Friche la Belle de Mai, Marseille

 

writing and photos: Jing Wan

modified: Zijun Feng

24 April 2022/by Jing Wan
https://www.enhpathy.eu/wp-content/uploads/2022/04/la-Fiche-meeting-1-scaled.jpg 1920 2560 Jing Wan https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Jing Wan2022-04-24 22:27:142022-04-24 22:39:09Science & Art collaboration: the starting up of Enhancer in Art

The collaborative nature of artists and scientists

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The truly collaborative nature of artists and scientists lies far from pop illustrations of the double helix in fancy journals. At some point, I had a temptation to create a scientific colouring book for kids that could be even published. However, I believe that talented kids will find another way to Science. I’m intended to dedicate my Enhancer in Art project to a more burning question for me.
In “The Nature of Paleolithic Art”, Dale Guthrie proves that most prehistoric cave arts were created by testosterone-fuelled boys, driven by sex and violent ideas. Interestingly, not much has changed, and we still see the same topics depicted on the street walls by modern young people. No taboos or other limiting factors could stop this ugly (or natural?) and uncontrolled energy from developing in punk rock, industrial and noise music in the 20th century (check “England’s Hidden Reverse: A Secret History of the Esoteric Underground” by David Keenan). What should we expect now from the metamodern era?
While Science keeps accumulating knowledge to move the borders further, Art, often based on poorly supported cultural norms, set up more and more experiments to refuse or even destroy them.

Leon Theremin plays theremin (Moscow, 1954)

5 April 2022/by Artemy Zhigulev
https://www.enhpathy.eu/wp-content/uploads/2022/04/Screen-Shot-2022-04-02-at-14.45.42.png 2240 3584 Artemy Zhigulev https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Artemy Zhigulev2022-04-05 00:50:472022-04-05 00:50:47The collaborative nature of artists and scientists

ART OF SCIENCE, SCIENCE OF ART ….

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People often perceive science and art are at the impassible spectrum, although it is a matter of observation and interpretation. For humans, the most effective method for interpreting the world around them is Visual Art. From prehistoric to the modern world, illustration has been the most effective way to explain the world around us and comprehend complex information clearly and concisely. Therefore the field of science and art are intimately connected. The detailed illustrations by artists and scientists significantly convey the knowledge and understanding of years of scientific research describing new species, anatomy and behaviour, complex processes, new technologies etc. This blog is dedicated to recognising SCIENTIFIC ILLUSTRATORS, a fascinating intersection between science and art.

 

“Science illustrators are artists in the service of science.”

– The Guild of Natural Science Illustrator

 

The practice of scientific illustration is an accurate and often artistic visual interpretation of a concept or idea aimed at the target audience. Therefore, A Scientific illustrator is an artist who has advanced education and specialised training in art, design, visual technology, media techniques, science, medicine and theories related to communication and learning. They collaborate with scientists, physicians, and other content specialists. They serve as a visual translator of complex technical information to support education, publishing content, medical and life science research, patient care and education, public relations, and marketing objectives. Apart from this, they can often function as content developers, creative directors, consultants to law firms/MNC and administrators within the general field of biocommunication. Many of them work as freelancers and emerge as entrepreneurs in the marketplace.

 

Scientific illustrators’ profession may not be as well recognised as teachers, astronauts or doctors since, after looking at the work of scientific illustration, many people assume that it is just a computationally created piece of art that you see in science textbooks, posters and advertisements. However, creating an illustration is a pretty extensive and complicated process, given they do a lot of reading, research and work with experts from all different fields. Creating an illustration is like starting with an idea, writing everything, thumbnails and brainstorming. It goes through various versions, drafts, corrections, and proofs until it ends with a final illustration.

 

As part of the “Enhancer in Art” science’art program, all the ESR are committed to finding a highly motivated artist to be involved in the project where they have to understand the depth of the project and bring artistic perspective to the edge that everyone can devour. Keeping this motivation in mind, I explored the plethora of scientific art and came across Tejeswini Padma, Professional Medical Illustrator (https://www.tejeswinipadma.com/). She is an award-winning medical Illustrator who creates bespoke and accurate artwork, animation and design for the medical, scientific and legal fields. It was amazing to meet her and be fascinated to see the medical illustration she had worked on. Lastly, here is one of her artwork I would like to present.

 

“When Nano meets Polymer” – Two miscible polymers interacting are shown by the boys playing. When subjected to extreme temperature changes, the polymers’ phase separate’, portrayed by the rift between the boys. The addition of nanoparticles (chocolates, candies and other goodies) helps keep these polymers together for longer, even in harsh conditions. Therefore the boys are back to playing together.

 

A classical Example of Scientific Illustration

Image Credit –
Tejeswini Padma, MS
Professional Medical Illustrator
Website: https://www.tejeswinipadma.com/
Linkedin: https://www.linkedin.com/in/tejeswini-padma-42b4b086/
Instagram: https://www.instagram.com/tpadma_illustration/

1 April 2022/by Abhishek Agarwal
https://www.enhpathy.eu/wp-content/uploads/2022/04/Tej_Nucleosome_for_AA_Enhpathy.png 2048 2048 Abhishek Agarwal https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Abhishek Agarwal2022-04-01 11:15:112022-04-01 12:12:19ART OF SCIENCE, SCIENCE OF ART ….

The Link Between Art and Science

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Many people believe scientific investigation only involves analytical thinking – a purely logical endeavor that is, unlike fine arts, free of any form of creativity. However, I have always seen scientific research and its integral problem-solving process as an inherently creative process. To me, the laws of nature and the analytical framework given by the scientific method only set the boundaries within which a scientist or engineer can act creatively to answer a question or solve a certain problem – much like artists are limited by their medium of choice. While our imagination may, to a certain extent, go beyond worldly constraints, painters will be limited by the canvas and the colors available to them, sculptors cannot go beyond our three dimensions, and musicians are bound to the tonal range of their instrument; to name but a few examples.
However, boundaries can also give rise to creativity, in art as well as science. The art is to fully express a conceptual idea despite the limitations.

A stunning example of creative thinking in science and its importance are Einstein’s thought experiments, most notably those related to his theory of relativity. At the time, recent developments in the field of electromagnetism (related to the Lorentz transformations) led to a mathematical model which implied that time and space would not be absolute. Inspired by this, Einstein considered various scenarios only using his imagination, with the mathematical model setting the creative boundaries. Without performing any hands-on experiments or setting foot in a laboratory, he formulated the theory of relativity. In his thought experiments he visualized beams of light that he is chasing, moving trains struck by lightning, or accelerating elevators and based on that reasoned out physical consequences. Through creativity and imagination, a scientific theory was born which still helps us in our daily lives (e.g., location tracking on our phones) and predicted phenomena we only managed to observe almost one hundred years later (gravitational waves were first observed directly in 2015).

Thus, I see art and science closely linked, with creative and imaginative aptitude forming the cornerstone for both – but one pertaining to emotion and the other to reason.

With Enhancer in Art, I hope my research will be translated from the world of reason to the world of emotion, therefore making it more approachable. This might help the layman, perhaps deterred by the analytical framework of science, to understand the creative process that science shares with art.

27 March 2022/by Robert Baber
https://www.enhpathy.eu/wp-content/uploads/2022/03/ScienceArtCreativity-e1648415067307.jpg 1462 1464 Robert Baber https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Robert Baber2022-03-27 22:23:012022-03-27 23:04:41The Link Between Art and Science

Role of art in a science-oriented world

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Modern industrial and post-industrial societies are increasingly relying on the scientific method for advancement of economy, citizen well-being and even culture. This shift from a more intuitive or, some would say, primitive way of thinking and decision making has undoubtedly benefited human race by accelerating technological progress and giving us an instrument for revealing the truth about the world in an unbiased manner. This understanding of universal usefulness of science is illustrated by the fact that most developed countries invest a great deal of money into various scientific programs without any obvious economic incentive. The explanation for that being the fact that long term positive effects of scientific development far outweigh the contemporary encumbrance of having to support costly research infrastructure. This atmosphere of increasing rationalization seemingly leaves little place for art to be of any significant value in the modern world.

This simplified view of the world, however, ignores major limitations of the scientific method. One being it’s focus on falsifiability, which in conjunction with technological limitations of our times effectively precludes the application of science to most of imaginable questions. Another big problem is the fundamental inconsistency of the mathematical framework that is at the heart of all modern science. This surprising quality discovered by Kurt Gödel in the first half of the twentieth century demonstrates a fundamental flaw in our understanding of logic and shows that no amount of technological or theoretical progress will provide us with a fully consistent view of the world. At the same time there are less metaphysical problems stemming from overspecialization. While overall scientific knowledge consistently grows, the fraction of it that can be internalized by any given person shrinks day-by-day. Each field grows deeper and deeper in it’s understanding of the subject, develops new jargon and narratives. As a result it is often a challenge to effectively communicate this information between the members of different fields, let alone between the scientists and general public.

But even if there are some cracks left to fill, could art be of any use in this endeavour? After all, art often serves a utilitarian function: as simple decoration, meaningless distraction, a profitable investment, a communication tool, at best a medium to share empathy and facilitate psychological support (nothing a future anti-depressant or anxiolytic can’t handle much more easily). The problem of overspecialization is also quite prominent in the art world. As any art form develops in it’s own rich historic and cultural context it acquires (deliberately or otherwise) footprints of the past: references to historic events, callbacks to previous works of art, callbacks to the aforementioned callbacks and so on and so on. A resulting work of art can become overburdened with information that without a substantial prerequisite knowledge is unreadable. To put simply, for a layman these pieces of art make as much sense as a physicist droning for hours about tensor products.

So, is there a role that art can play to help us with our understanding of reality? Does it need one? That I simply do not know. But being involved in the Enhancer in Art project I’m hoping that the process will help me to judge for myself.

24 March 2022/by Maksim Kholmatov
https://www.enhpathy.eu/wp-content/uploads/2020/11/Enhpathy_eia_sq_2.jpg 1000 1000 Maksim Kholmatov https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Maksim Kholmatov2022-03-24 01:36:072022-03-24 01:36:07Role of art in a science-oriented world

Cell signaling and gene regulation review

 

Cell signaling plays a crucial role in development and organisation of every tissue in a multicellular organism. Signaling pathways tend to result in the activation or inactivation of transcription factors (TFs), often through post-translational modifications of the TF, typically without altering their DNA binding specificity.

The TFs therefore are a subject to research from both fields of cell signalling and gene regulation. However, studying them from either point of view provides researchers with significant challenges largely caused by different technical limitations of each respective field.

Here I want to highlight a review we co-authored with our colleagues from EBI that illustrates many of these difficulties and highlights the importance of multi-omics studies to bridge these two aspects of TF biology in the future.

 

23 March 2022/by Maksim Kholmatov
https://www.enhpathy.eu/wp-content/uploads/2022/03/pmic13435-fig-0001-m.jpg 631 633 Maksim Kholmatov https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Maksim Kholmatov2022-03-23 22:48:072022-03-23 22:48:07Cell signaling and gene regulation review

A Sensory Play

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About the artist

 

 

With the bases of my Enhancer in art project in place, the next step was to find an artist whose vision and motivation aligned with not only me but the spirit of the project. When I set out to look for an artist, I had no idea that I would find one, an hour away from me. Soledad is a scientist and artist that has illustrated and designed more than twelve books, scientific dissertations, and journal publications. The trajectory of her life intertwines art and science at a very early age which goes on to diverge as she pursues a career in molecular biology. Eventually, in 2016, she finds solace in harmonising her passion for art and science which defines her brand now.

About the art

Soledad wanted to give the viewers an immersive visual and acoustic experience to convey the gravity of the project. With the installation art, she wants to emphasise how the disease is difficult to spot and analyse due to its intricate complexities. Her installation would encourage viewers to look at the disease from a different perspective.

The art piece encapsulates the serene nature of human development while eerily singling out the deteriorating heart. It introduces the experience with the banality of everyday lifestyle while the imminent detriment creeps in through an audio-ocular sensory play. The piece perfectly covers crucial aspects of the disease and sophisticatedly emphasises the weight of the problem.

The art aims to convey the importance of such research by giving viewers an experience to remember. With Soledad’s enthusiasm and vigour, I am looking forward to seeing everything come together.

 

Website: https://soledad2112.com

Linkedin: https://www.linkedin.com/in/soledadordonez/ 

Instagram : https://www.instagram.com/soledad2112/?hl=en 

 

3 March 2022/by Vartika Bisht
https://www.enhpathy.eu/wp-content/uploads/2022/03/Artboard-1.png 1080 1377 Vartika Bisht https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Vartika Bisht2022-03-03 18:15:582022-03-03 20:14:37A Sensory Play

Epromoters: The regulation of gene expression is no longer a binary issue

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In all mammals, the cellular operation responsible for the maintenance of homeostasis, specifically of all the physiological balances ensuring the vital functions of an organism, is dictated by the reading of information carefully preserved in the genetic heritage or DNA. The expression of a gene that will code for one or more proteins of interest is therefore a strategic step, controlled by the presence on this DNA of regulatory sequences, which in the event of malfunction, can cause the occurrence of serious genetic pathologies, such as inflammation or auto-immune diseases.

 

Listed in two distinct families according to their locations near or far from the genes that they regulate, researchers speak of promoters or enhancers, respectively. These sequences are scrutinized by the scientific community in an attempt to arrive at a better understanding of the complexity of their modes of action. The latest work from a research team within the TAGC laboratory (Theories and Approaches to Genomic Complexity, Inserm/AMU), led by Dr. Spicuglia and published in the journal Nature Communications have recently shed new light on the role of a particular family of promoters called Epromoter that are involved in gene regulation, but this time, without particular location criteria.

Read more

 

9 February 2022/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2022/02/New-Publication.jpg 800 800 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2022-02-09 11:47:422022-02-09 11:47:42Epromoters: The regulation of gene expression is no longer a binary issue

Epromoters: The regulation of gene expression is no longer a binary issue

In all mammals, the cellular operation responsible for the maintenance of homeostasis, specifically of all the physiological balances ensuring the vital functions of an organism, is dictated by the reading of information carefully preserved in the genetic heritage or DNA. The expression of a gene that will code for one or more proteins of interest is therefore a strategic step, controlled by the presence on this DNA of regulatory sequences, which in the event of malfunction, can cause the occurrence of serious genetic pathologies, such as inflammation or auto-immune diseases.

 

Listed in two distinct families according to their locations near or far from the genes that they regulate, researchers speak of promoters or enhancers, respectively. These sequences are scrutinized by the scientific community in an attempt to arrive at a better understanding of the complexity of their modes of action. The latest work from a research team within the TAGC laboratory (Theories and Approaches to Genomic Complexity, Inserm/AMU), led by Dr. Spicuglia and published in the journal Nature Communications have recently shed new light on the role of a particular family of promoters called Epromoter that are involved in gene regulation, but this time, without particular location criteria.

With an enlarged scope of action, Epromoters are forcing scientists to reconsider the origin of certain genetic dysfunctions

For the uninitiated, deoxyribonucleic acid, or DNA, a true emblem of modern biology responsible for the mechanisms of reproduction, mutation and gene expression, is a molecule discovered in the 1940s, whose double helix structure was revealed to the scientific community in 1953 by the famous duo Watson and Crick.

With the advent of ‘Omic’ technologies and new computing powers, researchers have constantly pushed the limits of knowledge on the complexity of this molecule, both organizationally and functionally. Three dimensional models of chromatin, the structure within which DNA is packaged, at the heart of epigenetics research programs, have replaced linear and simplistic models that tended to reduce the regulatory sequences of genes to simple switch boxes, attached to a gene, which the cell just needed to activate its button to influence the production of a protein.

Research work, which has enabled new actors to be characterized that are capable of inducing or repressing the activation of a gene from afar, has taken into account the complex re-arrangements in the space of the double helix, placing in near proximity certain regions that are several thousand base pairs apart, like a thread in a ball of wool.

A pioneer in the characterization of a group of promoters also involved in the regulation of distant genes (ref –> Genome-wide characterization of mammalian promoters with distal enhancer functions https://doi.org/10.1038/ng.3884), Dr. Spicuglia’s research team has taken a new step by confirming in this publication – notably thanks to functional studies involving key cellular players in the immune response, such as macrophages – the particular mode of action of Epromoters during the response of the cell to a stress signal or an inflammatory response.

Triggered by the body following an exogenous (infectious or traumatic) or endogenous attack, the inflammatory response is a component of the body’s immune response to a danger signal. Under normal conditions, it constitutes an adapted and controlled response by multiple regulatory systems, thereby contributing to the natural defense process and tissue repair. When the inflammatory reaction is inappropriate or poorly controlled, it becomes aggressive, doctors then speak of acute or chronic inflammatory syndromes or diseases, the latter being the third cause of death, after cardiovascular diseases and cancers.

Interferons, intercellular communication molecules and key players in the response to a stress signal

During a viral infection, type I interferons (IFNA/IFNB) are produced, proteins of the cytokine family which, by binding to their targets, will trigger an innate or immediate immune response, to limit the spread of the virus in the body. Secreted into the extracellular medium, IFNs are molecular messengers capable of docking in a specific way with membrane receptors to trigger a cascade of signals inside the cell; firstly in the cytoplasm, then in its nucleus, where they induce the expression of interferon-stimulated genes (ISGs).

“An insufficient or inappropriate interferon response will not be able to contain the replication of the virus or may promote a pathological immune response (for example, a runaway immune system, as seen in severe forms of Covid-19),” says Dr. Spicuglia.

Epromoters, multi-function regulating elements

The use in this study, of the so-called “high-throughput gene reporter system” technique for analyzing thousands of genome sequences presenting promoter or enhancer characteristics under different stimulation conditions, enabled Dr. Spicuglia’s team to show that the Epromoters are capable of not only locally recruiting all the factors involved in the regulatory mechanisms of ISG gene groups, but also of establishing connections with other distant genes during the induction of the cellular response to stress signals or during an inflammatory response.

“This observation now requires us to go further in the study of the mode of action of these regulatory sequences involved in inflammation to better prevent and treat the many diseases associated with it, such as atherosclerosis, cancers, auto-immune diseases and infections,” concludes Dr. Spicuglia.

 

Link to Nature Communications November 21 post: https://doi.org/10.1038/s41467-021-26861-0

Download this article here

Editorial: Jean M. Grangeon – KOM Agency
Review: Dr. Salvatore Spicuglia
Translation: David Williams

9 February 2022/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2022/02/New-Publication.jpg 800 800 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2022-02-09 11:44:542022-02-09 11:44:54Epromoters: The regulation of gene expression is no longer a binary issue

EMBO Workshop. Enhanceropathies | 06 – 09 October 2021

Understanding the mechanisms of eukaryotic gene regulation is essential not only from a theoretical scientific perspective. Knowledge of the precise mechanisms driving interactions between regulatory elements of a two-meter long DNA packaged inside a tiny nucleus is crucial for a better understanding of disease mechanisms. The gained insights ultimately may bring us closer to developing targeted strategies and solutions in the clinical setting.

During the EMBO Workshop, the leading scientists presented their recent works covering a broad range of topics in the field of enhanceropathies. Participation in the workshop allowed me to deepen my knowledge of enhancer biology and explore different computational and experimental approaches for studying the role of enhancers in development and disease.

15 January 2022/by Olga Pushkareva
https://www.enhpathy.eu/wp-content/uploads/2022/01/a3b91481-c303-429e-8e9a-20c7f5793cf1-2.jpg 1927 1714 Olga Pushkareva https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Olga Pushkareva2022-01-15 00:07:032022-01-15 00:10:44EMBO Workshop. Enhanceropathies | 06 – 09 October 2021

Enhanceropathies: Understanding enhancer function to understand human disease (EMBO workshop) 6-9th October 2021

During the EMBO workshop “Enhanceropathies: Understanding enhancer function to understand human disease” held in Santander (Spain)I had the pleasure of attending many interesting talks everything related to “enhanceropathies”.

No less important, I showed the recent results of my project during the poster session.
I am pleased to have aroused the interest of many colleagues who asked me interesting question and given above all useful advice.

Very good environment and excellent experience shared with other colleagues of consortium.

 

 

14 January 2022/by Francesco Leonetti
https://www.enhpathy.eu/wp-content/uploads/2022/01/20211008_082837.jpg 1042 966 Francesco Leonetti https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Francesco Leonetti2022-01-14 17:28:472022-01-14 17:40:17Enhanceropathies: Understanding enhancer function to understand human disease (EMBO workshop) 6-9th October 2021

EMBO Workshop Enhanceropathies, Santander Spain (6-9 October 2021)

I participated in the EMBO Workshop Enhanceropathies: Understanding enhancer function to understand human disease organised in Santander, Spain. I had the opportunity to broaden my knowledge and present the progress of my ongoing project through a poster titled: Dissection of enhancers community regulating the PPARG locus during adipogenesis.

Also, it was a great chance to meet PhD fellows from Enhpathy consortium. 

12 January 2022/by Anna Cetnarowska
https://www.enhpathy.eu/wp-content/uploads/2022/01/EMBO.jpg 1916 1482 Anna Cetnarowska https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Anna Cetnarowska2022-01-12 17:08:592022-01-12 17:11:04EMBO Workshop Enhanceropathies, Santander Spain (6-9 October 2021)

Enhancer in Art: The journey of Natsuda’s PhD — Artist introduction

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It takes me quite sometimes to figure this project out after I got the topic of “Enhancer in Art” from the ENHPATHY communication team. In brief, we would like to “publish” our research project on “enhancer” to more public eyes through “arts”, instead of a publication as usual.

After sat on it for quite a while, all the pieces of the puzzle were in place. For me, even though I have the concept of what to do since the beginning, doing research is still full of trial, failure, learning, adjustment, and, of course, readjustment. What I would like to present in my enhancer in art is, not only methods and results, but also the journey of my PhD research.

To capture this journey, I cannot think of anyone but my best friend Kalyarat “Farng” Kuropakornpong [@kalyakuropaa]. Drawing is what she has done for as long as we have met at 5 years old. She loves to draw her friends in different manners and occasions. I have had memories of us captured since.

     ||| “Looking forward to record the next chapter of your life”

is what she replied to me after I told her about this project. She is now a tea master and graphic designer in Thailand.

Another bff who will also be a part of this project is Kochamon “Ja-eh” Kanjanajan [@kettomotto]. Ja-eh is a software developer who has videography as a hobby. She just moves to Dubai and has started her own YouTube channel “Kate and Pat in Dubai”. She will record the journey of my research and Farng’s art in her prospective.

We are so excited to work together on this project and curious about what we will build together. Stay tuned for the next update 0f Enhancer in Art: The journey of Natsuda’s PhD with us !!!

Natsuda N    x    kalyakuropa    x    kettomotto

 

14 December 2021/by Natsuda Navamajiti
https://www.enhpathy.eu/wp-content/uploads/2021/12/S__6250624.jpg 906 1810 Natsuda Navamajiti https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Natsuda Navamajiti2021-12-14 18:08:062021-12-14 18:11:05Enhancer in Art: The journey of Natsuda’s PhD — Artist introduction

NanoBioTech-Montreux, Switzerland (15-17 November 2021)

The goal of this conference was to present my results achieved with the Elveflow droplet microfluidic platform through my poster contribution and discuss potential applications with other researchers of the nanobiotechnological field, thereby further building my professional network in addition to that.

19 November 2021/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2021/11/NanoBioTech-Montreux-Robert-Baber.jpg 519 875 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2021-11-19 08:57:222021-11-19 08:58:30NanoBioTech-Montreux, Switzerland (15-17 November 2021)

NanoBioTech-Montreux, Switzerland (15-17 November 2021)

The goal of this conference was to present my results achieved with the Elveflow droplet microfluidic platform through my poster contribution and discuss potential applications with other researchers of the nanobiotechnological field, thereby further building my professional network in addition to that.

17 November 2021/by Robert Baber
https://www.enhpathy.eu/wp-content/uploads/2021/11/NanoBioTech-Montreux-Robert-Baber.jpg 519 875 Robert Baber https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Robert Baber2021-11-17 07:45:292022-03-27 22:49:42NanoBioTech-Montreux, Switzerland (15-17 November 2021)

Blog 1: My EIA Expectations

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Being part of the Enhpathy consortium allows me, as well as all the other Enhpathy students, to team up with an artist. The idea is to introduce him/her to our project and participate in the creation of an artistic version of our research. Here, in this blog series I will share my personal progress and experiences on the Enhancer in Art project.

The intriguing combination of Art and Science

In recent years I have heard about many projects that aim to combine science and art. For instance, during my university studies I learned about the ‘dance your PhD‘ competition from the Science journal. For that PhD students record a short video of them dancing their projects. This is not only highly entertaining (i.e., dancing scientists) but also offered an alternative way for me to discover other research projects, I would have probably never heard about otherwise. I was hence thrilled that bringing together art and science is part of the Enhpathy program with the ‘Enhancer in Art’ initiative.

My Expectations

For me there are two main expectations for the Enhancer in Art project:

On the one hand, I am looking forward to learning more about science communication. As a researcher I often find myself being part of a science bubble. Of course, I have many opportunities to present my work, at conferences, meetings, in a publication and so on. Most of these events are however limited to researchers. Yet, we have come a long way from limiting science to a small group of men working on secret projects in their basements. On the contrary, many (non-science involved) people have become more and more interested in knowing about the developments on the forefront of science. We as researchers certainly have the responsibility to communicate our work. I hope that with the EIA I can practice and learn how to talk about my project to non-scientist. This will, without doubt, provide me with a skill, I would largely benefit from in my future career.

On the other hand, I aspire to get attention and excitement for my PhD project from a non-scientific audience. I intend to emphasize the importance of the work we as scientists and as a consortium are doing. I hope that by working together with an artist I will reach a broad audience. After all what better way to convey a message than through art?

Even though the EIA is outside of my normal science comfort zone, I am very excited about getting this part of the project started and hope to soon to be able to give an update on it.

 

 

 

 

18 October 2021/by Anna Karina Felder
https://www.enhpathy.eu/wp-content/uploads/2020/11/Enhpathy_eia_sq_2.jpg 1000 1000 Anna Karina Felder https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Anna Karina Felder2021-10-18 11:51:322021-10-18 12:49:07Blog 1: My EIA Expectations

MicroTAS 2021, Palm Springs, California, USA (10-14 October 2021)

As MicroTAS is one of the major international conferences in the microfluidics field, the objective was to connect with other researchers working on similar projects to build an international network that I could benefit from. With my poster, I presented the preliminary results of my single-nuclei ATAC-sequencing project with the aim of receiving feedback and input on this project.

14 October 2021/by Robert Baber
https://www.enhpathy.eu/wp-content/uploads/2021/11/MicroTAS-2021-Robert-Baber.jpg 520 692 Robert Baber https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png Robert Baber2021-10-14 08:52:532022-03-27 22:53:39MicroTAS 2021, Palm Springs, California, USA (10-14 October 2021)

The EMBO workshop starts today

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The new  EMBO workshop co-organized by Álvaro Rada-Iglesias, Salvatore Spicuglia and Susanne Mandrup and involving 6 Enhpathy’s students starts today. Please find more information about this event on the EMBO Workshop’s website.

About the Workshop

Due to the current COVID-19 emergency this workshop might need to be cancelled depending on national and local recommendations. In order to give both organizers and participants more time before making any decision, the registration and payment deadlines have been extended. In case of cancellation, registration fees will be reimbursed. We also recommend all invited speakers and participants to purchase their flight tickets with a cancellation insurance

Mutations within coding genes have traditionally been considered the major genetic cause of human disease. However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing and lifestyle (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, we currently have a limited understanding of human enhanceropathies. This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. To overcome these limitations, this workshop will bring together experts in enhancer biology, gene regulation and medical genetics that, during three days, will present their latest work. Our invited speakers and participants will discuss the multidisciplinary approaches required to investigate enhancer function as well as debate about the role of enhancers in fundamental biological processes (e.g. embryonic development, evolution) and in the etiology of human disorders. Ultimately, the goal of this EMBO Workshop will be to provide a complete view of how a deep and systems-level understanding of enhancer function can facilitate elucidating the molecular basis of human enhanceropathies.

 

6 October 2021/by KOM Agency
https://www.enhpathy.eu/wp-content/uploads/2021/10/EMBO-WS-starts.jpg 1000 1000 KOM Agency https://www.enhpathy.eu/wp-content/uploads/2019/11/logo-enhpathy-1.png KOM Agency2021-10-06 10:17:012021-10-06 10:17:01The EMBO workshop starts today
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