Sladana Kosanovic

In free time: artistic soul with musical and drawing tendencies.

Enhpathy will acquiesce me to accomplish goals I set up:

– development of scientific and transferable skills;

– to combine and implement scientific research into pre-clinical and clinical purposes;

– collaboration with other researchers and encounter new viewpoint on research and life.

My research project

Chronic inflammation represents a trigger for constantly active immune system and overproduction of cytokines and chemokines. This condition can promote several pathologies, such as type 2 diabetes, cardiovascular conditions, cancer, and dementia. Recently, we observed that chronic inflammation affects hematopoiesis, and in particular hematopoietic stem cell (HSC) function. The aim of this thesis is to analyze transcriptome changes and epigenome modifications in HSCs during chronic inflammation. CMO mouse strain (model of bone inflammatory disease) will be used as a model of chronic inflammation. This mouse model contains a point mutation in Pstpip2 gene resulting in the absence of Pstpip2 protein. Mice lacking Pstpip2 develop chronic multifocal osteomyelitis (CMO), a disorder that resembles human recurrent multifocal osteomyelitis. Hallmarks of this mouse model are sterile inflammatory lesions in the bones and surrounding soft tissues mainly in hind paws and tails, and a certain degree of skin inflammation.

To accomplish our aims, sequencing techniques such as ATAC-seq, ACT-seq, reduced representation bisulfite sequencing, and RNA-seq will be employed. Our results will determine chromatin accessibility, changes in histone modifications and DNA methylation, and changes in gene expression profile. The results of this project will contribute to a better understanding into the mechanisms driving the development of chronic inflammation, and might open new venues for the development of novel therapies.

My blog posts

My publications