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About ENHPATHY

A EUROPEAN TRAINING network (MSCA)

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ABOUT ENHPATHY

Training the new generation of researchers on the molecular basis of human enhanceropathies.

Opening new diagnostic and therapeutic avenues for patients. ENHPATHY is a multidisciplinary science consortium created in the frame of the Marie Sklodowska-Curie actions (MSCA)-ITN-ETN European Training Networks call and regrouping 15 academic and 12 non-academic European organisations in the continuum of basic, translational and clinical research on enhancers and associated diseases.

In genetics, enhancers are short regions of DNA that can be bound by proteins to increase the likelihood that transcription of a particular gene will occur. If mutations within coding genes have traditionally been considered the major genetic cause of human disease, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers and enhancer landscapes represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, there is a limited mechanistic understanding of human enhanceropathies. ENHPATHY aims to increase scientific knowledge and train the new generation of researcher on the molecular basis of human enhanceropathies to open new diagnostic and therapeutic avenues for patients.

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CONSORTIUM
ENHPATHY benefits from an international and multidisciplinary consortium of researchers
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A three-levels management structure
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Leading publications in the field of epigenetics
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LATEST NEWS

Current challenges in understanding the role of enhancers in disease

Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway

ENHPATHY ESRs visit the Novartis Institutes for BioMedical Research (NIBR)

Epromoters: The regulation of gene expression is no longer a binary issue

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Marie CurieThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 860002. The information contained in this website reflects only the authors’ view. REA and EC are not responsible for any use that may be made of this information.

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