Cell signaling plays a crucial role in development and organisation of every tissue in a multicellular organism. Signaling pathways tend to result in the activation or inactivation of transcription factors (TFs), often through post-translational modifications of the TF, typically without altering their DNA binding specificity.
The TFs therefore are a subject to research from both fields of cell signalling and gene regulation. However, studying them from either point of view provides researchers with significant challenges largely caused by different technical limitations of each respective field.
Here I want to highlight a review we co-authored with our colleagues from EBI that illustrates many of these difficulties and highlights the importance of multi-omics studies to bridge these two aspects of TF biology in the future.