Natsuda Navamajiti

My name is Natsuda Navamajiti from Thailand.

I am now a PhD fellow at Andersson Lab, the Section for Computational and RNA Biology, Department of Biology, University of Copenhagen, Denmark. I graduated from Chulalongkorn University, Thailand with a Bachelor’s Degree in Biology (Honours Program) and a Master’s degree in Biomedical Engineering (Bioinformatics). During my undergrad, I got an Erasmus Mundus Scholarship for exchange student in Bioinformatics at University of Toulouse III, France. In my master’s, I earned a great opportunity to expand the research field in drug delivery system at Langer Lab, MIT, USA. My previous research experiences related to machine learning model, lncRNA-proteins interaction prediction, and oral drug delivery system.

I spend my free time cooking and doing traditional Thai dance. I enjoy reading suspense novels, and running in the park.

My research project

We will focus on pediatric AMLs with dysfunctional transcription factors, which likely have a large effect on the activity of genes. CAGE (5’end RNA sequencing) will be used to characterize the transcription start sites and the abundance of produced RNAs. From these data, we will infer the activity of gene promoters and enhancers across AML patients. The association between regulatory dysfunction and clinical parameters will also be explored. 

Also, due to a large heterogeneity in cell populations, it is important to study transcriptional dysregulation on a single cell level. The scATAC-seq will allow us to measure chromatin accessibility at a single cell level to understand the regulatory potential in individual cells. Active regulatory elements are often accessible and transcribed, but many accessible regions are not active regulatory elements. By combining these scATAC-seq with bulk CAGE sequencing, we aim to infer the activity at the single cell level, thus revealing dysregulation at a cell type resolution.