Welcome to my first blog post!
I’m Sladjana Kosanovic and coming from Serbia. I finished Bachelor and Master Studies at the Faculty of Sciences, University of Novi Sad. This is the first time for me to leave my country for a long period of time and get out of my comfort zone. It was a long and tough process to become a member of a lab, but persistence is what leads you to success. Today I am proud member of great lab of Hemato-oncology located at the Institute of Molecular Genetics in Prague.
This is my first year of PhD studies so I am now at the beginning of the whole path with ups and downs. Some days are really tough, but the feeling you get after learning something new with upgrades in your project is priceless. I am happy that I can rely on my colleagues and mentor whenever I have a problem. Members of our team are always trying to support each other, give advice or hang out in a free time.
Now I will focus a little bit on scientific part of me being here. My project is related to chronic inflammation which is constant state of alert with overproduction of cytokines and chemokines. For a long period of time it leads to development of type 2 diabetes, cardiovascular conditions, cancer and dementia. As a model organism in this research we are using mouse strain which has a point mutation in Pstpip2 gene. Deficiency of Pstpip2 protein leads to development of chronic autoinflammatory disease called chronic multifocal osteomyelitis. Symptoms that characterize this strain of mice include lesions of bones and tissues surrounding hind paws and tail. The main aim of a project is to find epigenetic marks and genetic differences between wild type and CMO mouse strain using bioinformatic tools.